Cells respond to many cues from their microenvironment, which may include chemical signals, mechanical stimuli, and topography. Importantly, these cues may be incorporated into scaffolding to control cell function and optimize their ability to produce tissues in regenerative medicine applications. Despite the significant amount of work in this area, the availablity of highly functional materials and translationally-relevant materials has remained limited. To this end, we have developed a number of chemical approaches and technologies that include the ability to attach highly functional and bioactive groups to polymer constructs that include hydrogels, nanofibers and polymeric scaffolds. All are degradable and designed to be restorative or therapeutic in nature This presentiaton will highlight our recent efforts in this area.

Translationally relevant strategies for functional biomaterials

250th National Meeting (2015)

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