The purpose of this research is to study the influence of molecular parameters and field strength on the efficiency (relaxivity) of Eu(II)-containing cryptates as contrast agents for magnetic resonance imaging. Relaxivity is governed by several molecular parameters including rotational correlation time. The relaxivity of Eu(II)-containing cryptates with short and long rotational correlation times have been reported, but to understand how the interplay between rotational correlation time and field strength influences the relaxivity of Eu(II)-containing cryptates, complexes with intermediate rotational correlation times need to be studied. To fill this gap of knowledge, we synthesized host-guest adducts of biphenyl-functionalized cryptand with β-cyclodextrin and poly-β-cyclodextrin. We will present our results that compare rotational correlation time to relaxivity at a variety of field strengths. We expect that our results will be instrumental in the design of future Eu(II)-based contrast agents.

Effect of rotational correlation time and magnetic field strength on the relaxivity of Eu(II)-containing complexes

250th National Meeting (2015)

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