This is the first report of the synthesis of a new nanoparticle, Sans Iron Oxide Rhodamine B (SIRB), an example of a new class of nanoparticles, Sans Iron Oxide Nanoparticles (SION). SIRB is a nanoparticle designed to provide all of the cell labeling properties of the Ultrasmall Superparamagnetic Iron Oxide nanoparticle (USPIO), Molday ION Rhodamine B (MIRB). MIRB was developed to label cells and allow them to be tracked by MRI or manipulated <i>in vitro</i> or <i>in vivo</i> by magnetic gradients. SIRB possesses a similar size, charge and cross-linked dextran coating as MIRB (Table 1). Removing MIRB’s iron oxide core produces the new nanoparticle,SIRB) that we call (by analogy with the terminology used to name red cell ghosts) a USPIO ghost. The approach to synthesizing SIRB can be applied, in principle, to all cross-linked USPIOs. Examples of cell labeling with SIRB along with its toxicity profile are presented in a companion abstract.

SIRB, Sans Iron Oxide Rhodamine B, a novel cross linked dextran nanoparticle

250th National Meeting (2015)

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