Tuning the molecular recognition between proteins and nanoparticles (NPs) is of fundamental importance in therapeutic applications and sensor development. Considerable effort has been directed towards optimization of nanoparticles for effective interaction, however there has been far less exploration in terms of engineering of the protein partner. Here we report a strategy to enhance the affinity and selectivity of NP-protein interaction by co-engineering of both particle and protein. We will discuss effective strategies for generating robust NP-protein dyads.

Co-engineering the supramolecular nanoparticle-protein interface

250th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.