Resolution of chiral amines involves the selective modification of one enantiomer to obtain enantiopure product, however this process has a maximum yield of 50%. This can be increased by recycling the undesired enantiomer via a racemisation step.1, 2 The combination of catalysts often leads to a compromise in reaction conditions and so a reduction in efficiency. The use of a continuous system wherein the catalysts are isolated from one another would allow each catalyst to operate at optimum conditions. In this work, a recirculating continuous reactor set-up was developed to couple a lipase catalysed resolution to a metal-catalysed racemisation, to obtain enantiopure product. References 1. O. Verho and J.-E. Bäckvall, J. Am. Chem. Soc., 2015, 137, 3996-4009. 2. A. S. de Miranda, L. S. M. Miranda and R. O. M. A. de Souza, Biotechnol. Adv., 2015, 33, 372-393.

Combined chemo- and bio-catalysis for the dynamic kinetic resolution of chiral amines in continuous flow

251st National Meeting (2016)

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