4-Aminosalicylic acid (PAS) and Isoniazid (INH) are used as front line drugs for tuberculosis even today. Literature survey revealed that cinnamic acid amides of INH were found to be active against M. tuberculosis. Especially, methylenedioxy cinnamic acid amide of INH was found to have a minimum inhibitory concentration (MIC) of 3.25 mg/mL. Therefore, a series of amides with PAS and INH were prepared using piperic acid, methylenedioxy cinnamic acid and piperonylic acid as a part of molecular hybridization strategy to assess if the variation in chain length causes augmentation in the mycobacterial activity. The compounds 1a, b were tested in M. bovis BCG and M. tuberculosis H37Ra strains and were found to be significantly active on on M. tuberculosis H37Ra. The MIC of both the compounds were found to be 4 mg/mL. The others did not show any promising activity. The results indicated that it could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.

Synthesis of some new benzo[d][1,3]dioxoles and their antimycobacterial activity

251st National Meeting (2016)

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