The acyl carrier protein and peptidyl carrier protein are small proteins that mediate chemistry in fatty acid, non-ribosomal peptide, and polyketide synthase pathways. Human efforts to alter these pathways has been met with limited success due in part to a lack of detailed molecular information behind the carrier protein–partner protein interactions inherent to the pathways. This presentation will focus on recently developed tools for the modification of carrier proteins and analysis of protein–protein interactions, such as structural elucidtation, mechanism-based crosslinking, and the studies that exploiting these new tools for directing natural product pathways.

New technologies to understand and engineer carrier protein mediated pathways

251st National Meeting (2016)

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