Liposomes composed of natural or synthetic phospholipids are self-assembled colloidal vesicles that have shown great promise as therapeutic agents for the delivery of both hydrophobic and hydrophilic drugs. Despite their unique applications as drug delivery systems, liposomes suffer immensely from membrane permeability of encapsulated materials such as small molecules, ions, and drugs. As a biomedical application, this causes great concern for the passive leakage and accumulation of toxic drugs in undesired tissues. To address the problem of membrane stability, given their desirable and highly stable membrane properties, we focused our efforts on the synthesis and development of archaea-inspired lipids as stable lipid materials. To this end, we proposed a reasonable and facile synthetic route towards the synthesis of archaeal-type lipid analogues via click to generate a diverse library of lipids. In this presentation, we report the tunable and modular synthesis of archaeal-type lipids for the preparation of archaeosomes as new materials for potentially stable systems.

Facile synthesis of archaea-inspired lipids for the assembly of archaeosomes

251st National Meeting (2016)

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