High Throughput Experimentation (HTE) is often associated with brainless trial-and-error searches, but this is not necessarily the case. This talk will introduce a HTE workflow aimed to the rapid implementation of large and accurate structure-properties databases in polyolefin catalysis, in view of predictive QSAR modelling. A state-of-the-art secondary screening platform operating at high pressure was integrated off-line with advanced polyolefin characterization tools including high temperature cryoprobe <sup>13</sup>C NMR, Rapid Gel Permeation Chromatography and Analytical Crystallization Elution Fractionation. Compared with a conventional approach, a 10<sup>2</sup>-fold throughput intensification was achieved without losing in precision and accuracy. Application to classical Ziegler-Natta catalysts for polypropylene production will be used as a case history.

Focusing the HTE approach to polyolefin catalysis

251st National Meeting (2016)

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