Natural polysaccharides derived from plants, animals and microorganisms are widely used but also newly emerging materials in a broad spectrum of biomedical and life science fields. (Basu et al. 2015; Liu et al. 2015; Shelke et al. 2014) Besides their biological recognition, biocompatibility, low-toxicity, biodegradability and specific therapeutic activities, polysaccharides offer a divers set of physicochemical properties based on the type of monosaccharide that constitute the chain, their composition, source and physical structure. In addition, they possess many functional groups (e.g. hydroxyl, amino, carboxyl and sulfate groups, which can be utilized for further modification to meet varying demands from science and technology. (D’Ayala et al. 2008) 2D (thin films) and 3D polysaccharide matrices and their composites (e.g. electro spun mats, 3D printed objects, aerogels, blends of derivatives and synthetic polymers) feature a specific structure which can be used to study protein- or cell-surface interaction by state-of-the-art surface sensitive analytical methods. (Maver et al. 2015) Materials designed in this way yield spatially resolved patterns, wettability, charges and chemical composition, which subsequently allow targeted adsorption of proteins and cells, leading to highly functional polysaccharide materials. In this talk new structuring methods for two and three dimensional materials, their tunable surface properties and site-specific interactions with biological molecules and living matter will be presented. Basu, A., Kunduru, K. R., Abtew, E., & Domb, A. J. (2015). Polysaccharide-Based Conjugates for Biomedical Applications. Bioconjugate Chemistry, 26(8), 1396-1412. Liu, J., Willför, S., & Xu, C. (2015). A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications. Bioactive Carbohydrates and Dietary Fibre, 5(1), 31-61. D’Ayala, G., Malinconico, M., & Laurienzo, P. (2008). Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches. Molecules, 13(9), 2069. Maver, T., Hribernik, S., Mohan, T., Smrke, D. M., Maver, U., & Stana-Kleinschek, K. (2015). Functional wound dressing materials with highly tunable drug release properties. RSC Advances, 5(95), 77873-77884. Shelke, N. B., James, R., Laurencin, C. T., & Kumbar, S. G. (2014). Polysaccharide biomaterials for drug delivery and regenerative engineering. Polymers for Advanced Technologies, 25(5), 448-460.

Development of structured polysaccharide based materials for biomedical applications

251st National Meeting (2016)

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