The monobocylation of 1,3-diaminopropane and other diamines have been optimized at reduced temperatures under continuous flow conditions. The optimization process, facilitated by the use of a Labtrix Start microreactor, allowed for the production of the desired carbamate in moderate to high yields at reduced temperatures. Monobocylation has now been optimized to both increase production of single protected amine and decrease production of the bis-protected amine.

Monobocylation of diamines in continuous flow

251st National Meeting (2016)

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