Salicylic acid (SA), an anti-inflammatory drug, has shown potential to prevent many diseases including diabetes and cancer. In this research, SA chemically incorporated into hydrogel systems. Hydrogels have been received attention in many biomedical applications including, protein delivery and wound dressing owing to their ability to tune easily and similarity to natural living tissue. In this research, SA was chemically incorporated into hydrogel systems via attachment of SA to an itaconate moiety followed by crosslinking using acrylic acid and poly(ethylene glycol) diacrylate via UV initiation.<br/>SA-based hydrogels showed pH-responsive behavior, collapsing at acidic pH (pH 1.2) and swelling at higher pH (pH 7.4). The structure, swelling behavior, pore structure, SA release, rheological, and mucoadhesion behavior of these hydrogels were studied. These networks exhibit promising pore size for physically encapsulating of drugs and proteins. Furthermore, SA release behavior of these hydrogels was evaluated. The hydrogel systems exhibit a pH-dependent SA release profile. In pH 1.2, SA release was much slower compared to pH 7.4. Under acidic pH, 30% SA was released after 24 h, and 100% SA was released in a sustained manner within 24 h in pH 7.4 buffer. In addition, rheological studies of the hydrogels proved that these systems are mechanically strong and robust. Moreover, these hydrogel systems also showed mucoadhesive behaviors, which is important for drug delivery applications. These results suggest that SA-based hydrogels can be potentially used for oral delivery of proteins and small molecules in combination with SA to treat cancer and diabetes.

Novel salicylic acid-based chemically cross-linked pH sensitive hydrogels for biomedical applications

251st National Meeting (2016)

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