Polymeric hydrogels have been extensively explored as drug delivery vehicles due to their high water content, tunable viscoelasticity, and biocompatibility, which allow the release of bioactive molecules from the hydrogel in a controlled manner. Herein, we present the development of various responsive polymeric matrices ranging from bulk to nanoscale for different biomedical applications. First, we describe the engineering of a library of hydrolytically degradable polyethylene glycol (PEG) hydrogels formed by Michael-type addition for the sustained delivery of an anthrax toxin-neutralizing monoclonal antibody. Second, we introduce the design of a glutathione-sensitive, liposome-crosslinked hybrid hydrogel for the controlled and sequential delivery of multiple cargo molecules that are relevant for chemotherapies. Finally, we demonstrate the facile preparation, from liposome templates, of novel, polymeric nanogels that are crosslinked by photo-triggered Michael-type addition. Taken together, these matrix platforms provide a powerful toolbox for the controlled delivery of therapeutic molecules in various biomedical applications.

Engineering responsive matrices for controlled drug delivery: From bulk gels to nanogels

251st National Meeting (2016)

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