The ability of supramolecular nanostructures to break down in response to physiological stimuli is a prerequisite for their use as drug or imaging agent carriers. The pathways and kinetics of disassembly would have an important impact on cargo release rates and their ability to fulfill their biological roles. In this presentation, I will report our recent progress in understanding of the disassembly and immolation pathways of drug-based supramolecular polymers. Our results revealed that the reducing agent glutathione could directly attack supramolecular assemblies at defects of packing, which leads to a cascade of nanostructures breakdown and reassembly.

Disassembly and immolation pathways of drug-based supramolecular polymers

251st National Meeting (2016)

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