One-component nanomedicine (OCN) represents an emerging class of therapeutic nanostructures that contain only one type of chemical substance. This one-component feature allows for fine-tuning and optimization of the drug loading and physicochemical properties of nanomedicine in a precise manner through molecular engineering of the underlying building blocks. Unlike traditional carrier-based nanomedicines that are inherently multicomponent systems, an OCN does not require the use of additional carriers and could itself possess desired physicochemical features for preferential accumulation at target sites. I present here our recent progress in the molecular design and fabrication strategies of OCN, and discuss the opportunities that this emerging platform could open for the new and improved treatment of devastating diseases.

One-component nanomedicine

251st National Meeting (2016)

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