Smart polymers are those polymeric materials that have the characteristic of show an abrupt change in their physicochemical properties in the presence of external stimuli such as temperature and pH.1 Such materials have been attracted great interest within the scientific community because of their potential application in the controlled release of drugs2. The use of gamma radiation has some advantages over conventional methods due to is not necessary the use of chemical initiators or catalyst.3 Silicone rubber is a polymeric material widely used in the biomedical field and can be modified grafting polymer chains that can improve the physicochemical properties and its biocompatibility. This work focuses on the modified silicone rubber to synthesized novel thermo and pH sensitive materials using gamma irradiation, grafting of N-vinylcaprolactam (NVCL) and 4-vinylpyridine (4VP) by one step method to obtain a hydrophilic material, and evaluate the effect of radiation conditions on the grafting yield, as dose and monomers concentration factors that determine the characteristics of a material with potential application in drug delivery systems, biomaterials were characterized by FTIR-ATR, raman, DSC, TGA, swelling degree in order to study silicone pristine and modified films and the stimuli response was carry out using buffer solutions for pH critical point and temperature changes for Upper Critical Solution Temperature (UCST) behavior. Graft copolymers of SR-g-(NVCL-co-4VP) showed good cytocompatibility against BALB/3T3 cells; amount of drug loaded showed dependence of solution drug concentration. Drug release studies were performed at pH 7.4 and 37 °C.

Novel copolymers thermo and pH-sensitive of poly(N-vinylcaprolactam-co-4vinylpyridine) onto silicone rubber for drug delivery

251st National Meeting (2016)

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