The sesquiterpene obtusanal was originally isolated from the heartwood of <i>Chamaeparis obtuse</i> in 2001. This natural product features a densely packed framework including two all-carbon quaternary centers and an aldehyde motif. Our synthetic approach employs a proline sulfonamide-catalyzed Yamada-Otani cyclization, sequential palladium cross-couplings and a late stage intramolecular aldol reaction.

Synthetic studies towards obtusanal

251st National Meeting (2016)

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