Heterocycles are prevalent motifs seen in numerous biologically active natural products and pharmaceuticals. This presentation will describe a practical approach for the construction of decorated heterocycles based on the trapping of in situ-generated cyclic alkyne intermediates. Additionally, observed regioselectivities in reactions of unsymmetrical cyclic alkynes will be discussed.

Cyclic alkynes as useful synthetic building blocks

251st National Meeting (2016)

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