Natural Killer T (NKT) cells are a subset of T cells that play a central role in regulating immune responses. α- Galactosylceramides (α-GalCers) are known to stimulate these NKT cells. SAR studies on a synthetic α- GalCer, KRN7000, led to the development of various analogues with different immunostimulatory properties (Th1 or Th2). To further understand the biological importance of α-Galcers and to study the influence of structural modifications on NKT cell responses, in this work we describe the synthesis of a series of carbohydrate-modified analogues of α-galactosylceramides and report their ability to stimulate NKT cells.

Synthesis of carbohydrate modified analogues of α-galactosylceramide for NKT cell activation

251st National Meeting (2016)

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