This summer, I researched the total organic of synthesis of (+)- and (–)- parthenolide while completing an international research experience in Jena, Germany. The natural product (–)-parthenolide has much potential as an anti-cancer therapeutic because of its ability to selectively induce apoptosis in cancer stem cells, effectively killing cancer “at the root of the cause” while leaving healthy cells intact. Much research has been completed trying to determine the structure-related activity of the molecule and increase the potency; however, much is still unknown. Here we discuss a synthetic approach for (+)- and (–)-parthenolide to further analyze the pharmacological properties of the naturally occurring parthenolide and its unknown enantiomer. While in Germany, I learned about international science and collaboration. Outside of the lab, I broadened my horizons and learned about cross-cultural communication.

Research towards the total organic synthesis of (+)- and (–)-parthenolide in Jena, Germany

251st National Meeting (2016)

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