In this contribution, we have investigated the efficacy of heterogenous palladium catalysts in the Catellani reaction. Use of Pd EnCat® 30 and Pd/Al2O3 as catalysts led to fairly high yields and good selectivity (41-79%), though leaching of palladium into solution poses an issue for the contamination of the final product. In addition, γ-valerolactone, a chemical derived from lignocellulosic biomass, was shown to be a sustainable solvent suitable to replace classical organic media for this reaction.

Heterogeneous palladium-catalyzed catellani reaction in a sustainable media

251st National Meeting (2016)

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