Nanocarriers, 10-30 nm in size, have unique advantages to improve therapeutic efficacy for drug delivery and vaccine formulation due to their ability to cross different biological barriers and undergo deep tissue penetration. However, micelles in this size range have limited <i>in vivo</i> stability, serious cargo leakage and rapid disassembly mainly due to their poor kinetic stability. We have developed 15 nm nanocarriers called “3-helix micelle” (3HM) based on amphiphilic peptide-PEG conjugates that  has a long blood circulation (t1/2 ≈ 29 hours), selective accumulation of in tumors and reduced accumulation in the liver and the spleen. I will report our recent studies to systematically understand the design principle to obtain micelles with tunable dynamic stability, controlled cargo release profile and multivalent ligand presentation.<br/>

Design amphiphilic peptide-polymer conjugates toward modular nanocarrier

251st National Meeting (2016)

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