Cis-diammine (1,1-cyclobutanedicarboxylato) platinum (II) also known as carboplatin is known to be the second generation anticancer drug that is commonly used for treating lung, head and neck, ovarian and testicular cancer.  Oxaliplatin and nedaplatin (cisplatin derivatives drugs) are routinely employed in the treatment of colorectal cancer, uterine cervical, head and neck, and urothelial cancer. In this presentation, we have utilized normal Raman (NR) and surface-enhanced Raman scattering (SERS) techniques to obtain vibrational spectra of the anticancer drugs. SERS samples were prepared by dissolving the desired sample in deionized water, adding silver nanoparticles to the solution and finally incorporating NaClO4 salt to the sample. In this work, RS and SERS spectra of anticancer drugs under various conditions such as concentration and temperature will be presented. A comparison between these second generation drugs and cisplatin will also be discussed.<br/>

Surface-enhanced Raman scattering of cisplatin derivatives: Carboplatin, oxaliplatin and nedaplatin

251st National Meeting (2016)

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