The engineering of therapeutic proteins has been advanced enormously by methods for site-directed mutagenesis.  This lecture will describe an alternative, complementary approach, in which non-canonical amino acids are used to engineer protein-protein interactions, protein solvation and chain trajectory, with the objective of controlling the stability and pharmacokinetics of protein therapeutics.<br/>

Non-canonical amino acids as tools for protein medicinal chemistry

251st National Meeting (2016)

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