Micelles with anfifilic characteristics have been widely research over the past few years due to their possible applications as drug carriers. N-Vinylcaprolactam has been long study because its biocompatible material approve by the FDA, making it ideal for applications as biomaterials. In this work we have synthesized micelles with anfifilic characteristics of block copolymers of poly (N-Vynilcaprolactam-b-hexile acrylate) in water dispersion, block copolymers were polymerize by RAFT polymerization, getting controlled molecular weight and polydispersity, polymers were characterized by dynamic light scattering. Micelles were formed by dispersion in water; right conditions of micellization were obtained. The results obtained demonstrated that anfifilic micelles of block copolymers poly (N-Vynilcaprolactam-b-hexile acrylate) can be prepared via RAFT polymerization obtaining good molecular weight control while having low polydispersity, these micelles prove to be pH and temperature responsive. These results suggest that these micelles can have a potential use as drug carriers.

Synthesis and characterization of nanohydrogels prepared by gamma irradiation of thermosensitive micelles of poly(N-vinyl caprolactam)-b-poly(hexyl acrylate)

251st National Meeting (2016)

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