We will describe the design of a resistively heated reactor for flow chemistry. Heat is generated by running a current through a stainless steel tubing.[1-4] The reactor cavity has a small foot-print and the exchangeable stainless steel tube reactors are in the initial design capable of several grams per hour production rates. The reactor is designed with ease of use in mind and can easily provide temperatures of several hundred degrees Celsius. We will in addition present initial chemistry examples including benchmarking reactions such as the Fischer-Indole reaction and the Suzuki-Miyaura coupling as well as new chemistry performed in a continuous-flow fashion. References: [1] Kunz, Ulrich, and Thomas Turek. "Flow through reactors for organic chemistry: directly electrically heated tubular mini reactors as an enabling technology for organic synthesis." Beilstein journal of organic chemistry 5.1 (2009): 70. [2] Gutmann, Bernhard, et al. "Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor." Beilstein journal of organic chemistry 7.1 (2011): 503-517. [3] Schlange, Alicja, et al. "Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current." Beilstein journal of organic chemistry 7.1 (2011): 1412- 1420. [4] Grimm, Heiner, and Ulrich Kunz. "Continuous fuel cell catalyst preparation in a directly electrically heated tubular reactor." Chemical Engineering & Technology (2015).

Bench-top resistively heated reactor for flow chemistry

251st National Meeting (2016)

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