We have prepared a biodegradable polymer inspired by the backbone of Poly(lactic-<i>co</i>-glycolic acid) with pendant azide groups built into the structure. These pendant azides provide an ideal platform for further modification of the polymer. We have worked to modify the polymer directly using copper catalyzed click chemistry to to tests its ability to act as a polymer prodrug conjugate. We have also formulated the polymer into polymeric nanoparticles. These particles are shown2 to be capable of functionalization with copper free cyclooctyne based click strategies with model dyes. This novel material has great potential for targeted drug delivery applications.

Poly(lactic-<i>co</i>-glycolic acid)-based clickable polymer

251st National Meeting (2016)

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Poly(lactic-co-glycolic acid)-based clickable polymer