<br/>A wide range of valuable databases, both academic and commercial, use the curation model to extract and standardise selected result sets from the literature. This is the classic unstructured-to-structured transformation, predominantly of target binding data (e.g. IC50, Ki or Kd) between ligands and targets. Since 2009 the the Guide to PHARMACOLOG (GoPdb) has now curated quantitative interactions between 1300 protein targets and 6000 ligands covering a substantial proportion of the druggable proteome. The team has thus considerable expertise in the challenges of standardisation. This needs to be interposed between not only the primary literature but also other the databases that have extracted data. The wide range of compatibility and other issues associated with selecting new content for GtoPdb will be outlined. These will include the problem of equivocal measurement units as well as non-standard chemical IDs, protein IDs being used by authors. The issue of data gaps will also be expanded on. The presentation will conclude with an assessment of new initiatives from several publishers for authors to mark-up their chemical compounds before publication.

Virtues and vicissitudes of curatorial data wrangling: The guide to pharmacology experience

251st National Meeting (2016)

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