Among the diverse reactions catalyzed by metalloenzymes, the titled ones are among the most important and complex. In determining "How These Enzymes Work", Paramagnetic resonance methods can uniquely give information about the electronic and geometric structures of freeze-trapped catalytic intermediates, as well as the kinetics of their interconversion. This talk will discuss how this information can be used to reveal key elements of enzyme catalytic mechanism (non-heme Fe enzymes) and in the most complex of metalloenzymes (nitrogenase) even completely the determination of mechanism.

Paramagnetic resonance methods and enzymatic [e-/H+]/[H] addition & extraction

251st National Meeting (2016)

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