The International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) provides authoritative reports on G protein-coupled receptors (GPCRs) Nuclear Hormone Receptors and Ion Channels as pharmacology-based classifications. While these recommendations surfaced as Pharmacological Review papers (i.e. unstructured) since the 1990’s, they were already underpinning the protein tables in GtoPdb's predecessor, IUPHAR-DB, by 2003. By 2012 this hierarchical data structure had expanded into the GtoPdb schema covering essentially all target classes for pharmacology, drug discovery and chemical biology. As of August 2015 the expert-curated relationship capture from the literature covers 1505 target-to-ligand mappings of which 1228 human protein IDs have quantitative interaction data recorded against 5860 chemical structures. The motivation, evolutionary trajectory, the need for community engagement to fill data gaps and future directions of the resource will be outlined. Descriptions will cover the challenges of cross-referencing alternative gene/protein hierarches, each of which has different navigational utilities and linkages to chemistry in GtoPdb. These now extend beyond receptors to enzymes and include NC-IUPHAR, HGNC, UniProt, Ensembl, InterPro, Gene Ontology and E.C. numbers. The adaption of our classifications to encompass a new immunopharmacology project will also be discussed.

IUPHAR/BPS guide to pharmacology (GtoPdb): Concise mapping for the triples of chemistry, data, and protein target classifications

251st National Meeting (2016)

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