Higher level of hydrogen peroxide in body tissues contributes to oxidative stress that might cause the development of neurodegenerative diseases, cardiovascular diseases, and cancer. Various polymeric structures have been developed to degrade in the environment with hydrogen peroxide. Here we synthesized two new self-immolative polymers bearing aryl boronic ester moieties. In the presence of hydrogen peroxide, these two polycaprolactone- and poly(lactic-<i>co</i>-glycolic acid)-based polymers degraded via oxidation and hydrolysis of aryl boronic ester as well as intramolecular cyclization. This work provides new polymeric scaffolds for polymeric delivery system responsive to hydrogen peroxide.

Degradation of self-immolative polymers in response to hydrogen peroxide

251st National Meeting (2016)

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