Covalent cysteine modulators have been utilized in the study of a variety of biological processes, including the regulation of proteins via ubiquitination, sumoylation, prenylation, farnesylation, phosphorylation and glycosylation, etc.  In this regard, we report the synthesis of structurally diverse electrophilic sultam scaffolds as modulators of cysteine functionality within proteins.  Several reaction pathways are utilized for the facile synthesis of an array of monocyclic and bicyclic electrophilic sultams.  Corresponding reactivity profile studies will also be discussed.<br/>

Electrophilic sultams: Synthesis and reactivity

251st National Meeting (2016)

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