The rational design of small organic molecule as chemosensors for ion detection has been a hot topic in recent years. 1,4-Disubstituted-1,2,3-triazole motifs have been used extensively in these types of sensing applications. In practice, triazo scaffolds have been incorporated into chemosensors as a part of the signaling component or simply as ligation tool to link the chelating unit to the signaling moiety. With respect to their chelating properties, triazole systems have the ability to bind both cations and anions. The 1,2,3-triazo units are N-donors during cation chelation and H-bond donors <i>via</i> the sp<sup>2</sup>C-H during anion binding. The triazole probes are often made using the Click reaction, an elegant synthetic approach which is a high yielding and atom economical process that allows relatively quick access to the molecules and an efficient means by which the selectivity and specificity of the probes can be tuned with the choice and position of functional groups. Here in, we will detail our efforts toward the synthesis and development of novel 1,2,3-triazole colorimetric and fluorimetric sensors.

Inspired by chelation drugs, 1,2,3-triazole chemosensors: Synthesis and application

251st National Meeting (2016)

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