We report the first synthesis of highly polar hyperbranched aminobisphosphonic acid polymers via reversible addition fragmentation chain-transfer (RAFT) self-condensing vinyl polymerization (SCVP). The polymer is created by RAFT polymerization of an amine functional acrylamide monomer with a chain-transfer monomer (CTM), followed by a three component Kabachnik-Fields reaction. Employing a one pot multicomponent reaction (MCR), serves as an efficient tool to create the highly functional pendant chain on the polymer. To our knowledge, this is the first report utilizing an MCR on a RAFT-derived hyperbranched polymer. Using RAFT as the polymerization method results in well-defined polymers with controlled and pre-determined degrees of branching. The final functionalized polymers are highly polar, water-soluble, and show interesting solution behavior that is influenced by the degree of branching. These polymers may have useful applications in a variety of fields, such as metal chelation or drug delivery.

Hyperbranched phosphonic acid polymers via RAFT-SCVP

251st National Meeting (2016)

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