We recently developed a novel method to functionalize enamines at the alpha position <i>via</i> an intermediacy of azaallyl cation intermediate. The wide range of substrate compatibility were showcased by not only the variety of nucleophiles, but also the various side chain substituents. The novelty of this method is further highlighted by our ability to control the regioselectivity. Furthermore, the stability of the facile enamine functionality underscored the mildness of our reaction conditions.

Functionalization of enamines via aza-allyl cations

251st National Meeting (2016)

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