Recently thermoresponsive polymers have been increasingly investigated in nanotechnology and biotechnology applications. Synthetic (macro)molecules exhibiting a lower critical solution temperature (LCST) in water are structures of prime importance in applied polymer research[1]. There has been a great interest on responsive polymeric micelles over the last few decade. Such structures are generally called as smart materials which have stimuli responsive nature. Indeed, these water-soluble polymers precipitate over their LCST[2]. In case of thermoresponsive polymers, temperature can be used as a simple external trigger to change the conformation of the polymer. Poly(N-isopropyl acrylamide) (PNIPAM) and its copolymers are one of the most frequently used thermoresponsive systems with various accomplished applications[3]. Some literature reports showed that certain cell types can accept thermosensitive PNIPAM containing colloids. However, contradicting toxic behavior of PNIPAM formulations, in particular at the decadent-hydrophobic state was also reported. To improve the antifouling properties of thermosensitive colloids, either incorporating thermosensitive poly(ethylene glycol) containing methacrylate (PEGMA) units or directly usage of PEGMA polymers can be applied as an excellent alternative [4]. Herein, new PEGMA colloids having different LCST values ranging from 32 to 90 oC are successfully synthesized and characterized by using DLS, UV, and FTIR. The thermoresponsive characteristics of all synthesized PEGMA nanoparticles are explored and compared. Controlled drug and fluorescent dye release mechanisms of these PEGMA colloids are investigated under conventional heating or laser ablation (photothermal). Acknowledgements This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK Grant 214M232 and 112M096) and Selcuk University Scientific Research Fund (BAP). References 1. Lutz, J.-F., A. Hoth, and K. Schade, Designed Monomers & Polymers, 2009. 12(4): p. 343-353. 2. Ulasan, M., et al., J Biomed Mater Res A, 2015. 103(1): p. 243-51. 3. Yavuz, M.S., et al., Journal of Polymer Science Part a-Polymer Chemistry, 2011. 49(22): p. 4800-4808. 4. Lutz, J.F., et al., Macromolecules, 2007. 40(24): p. 8540-8543.

Fabrication of thermoresponsive PEGMA colloids for controlled drug delivery

251st National Meeting (2016)

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