Toxicity of particulate matter (PM) is believed to be source and composition dependent and the relationship between PM composition and toxicity is still not well known. In this study, five PM samples were collected directly from emissions of wood, crop residue, coal, and diesel combustion. A sample from cigarette smoking and two samples from ambient environment were also collected for comparison. The samples were characterized for their physicochemical properties and tested for the production of inflammatory cytokine (TNF-α) and the level of intracellular reactive oxygen species (ROS) using Raw264.7 cell line. It was found that more ROS were generated when the cells were exposed to PMs from biomass burning origin, while levels of TNF-α induced by the PM from the two ambient samples were significantly higher than those induced by other PM samples. The relationship between the physicochemical properties and in vitro cytotoxicity is discussed.

Effects of particulate matter from different sources: An in vitro study

251st National Meeting (2016)

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