The oxime ether compounds containing 1,2,4-triazole moiety have been widely reported as fungicides. They play an important role in the discovery and development of new agrochemicals, however, the compounds of this kind had not been published with herbicidal activity. To find new compounds with high herbicidal activity, the novel carboxylic ether derivatives containing oxime were designed and synthesized by introducing the herbicide carboxylic acid into traditional triazole compounds via the intermediate derivatization method. The structureactivity relationships of the synthesized compounds was also discussed. The structures of all target compounds prepared were confirmed by 1H NMR, IR, MS and elemental analysis. <br/>Bioassays indicated that most of the title compounds exhibited high herbicidal activity against gramineous weeds and broadleaf weeds. Some compounds displayed more than 95% control against Zinnia elegans Jacq., and Abutilon theophrasti Medic. at 150~300 g (a.i.)/hm2, and it was safe to corn at this dose. The present work demonstrates that carboxylic ether derivatives containing oxime can be used as potential lead compounds for developing novel herbicides. Further syntheses and structure optimization studies are in progress.<br/>

Design, synthesis, and biological activities of novel carboxylic ether derivatives containing oxime

251st National Meeting (2016)

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