Cognitive processes involve multiple mechanisms which  interact in complex, and possibly idiosyncratic ways. Monopharmacological treatments for brain disorders (including  cognitive decline and dementia) have therefore had little impact on the disorders. There is increasing evidence that certain dietary components can impact positively on cognitive function during aging. It may be that by affecting multiple systems, bioactive nutrients, including widely consumed plant flavonoids such as curcumin may offer a more promising approach.<br/>This talk will draw on specific examples from a ten year systematic assessment of the behavioural effects of dietary interventions focusing on a recent trial on the cognitive effects of Longvida™ a highly bioavailable curcumin preparation.<br/>In a double-blind, placebo-controlled trial, a cohort of healthy older individuals (n = 60, aged 60- 85 yrs) underwent a series of standardised tests of mood and cognitive function both acutely and following 28 days curcumin supplementation ( 400 mg Longvida™ extract containing 80 mg curcumin). Acute effects of curcumin included improved working memory and attention. Following the 28-day intervention, the working memory effect was maintained and there was a significant reduction in fatigue (as measured using standardised self-report measures) and cholesterol. Undertaking the cognitive test battery itself acted as a psychological stressor, increasing negative mood. The curcumin group were significantly protected against this effect, specifically showing significantly reduced fatigue and increased calmness and contentment compared with the placebo group.<br/>Dietary flavonoids from a number of sources are capable of improving neurocognitive functioning both acutely and chronically. The RCT demonstrating benefits to mood and cognition add to a growing body of evidence of a number of health benefits following oral curcumin consumption. The mechanisms underlying the effects are not currently known but may relate to documented blood flow, anti-oxidant status and anti-inflammatory effects. Further work is needed to  both replicate the behavioral effects and to explore the underlying mechanisms.

Dietary bioactives and neurocognitive function: The case for curcumin

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.