We demonstrate an electrostatic assembly approach to perform a controlled synthesis of (1) the silica microsphere (m-SiO2) with the surface-decorated functional gold nanoparticle (AuNPs), and (2) the silver nanoparticle (AgNP)-graphene oxide (GO) hybrid nanomaterial. For the fabrication of m-SiO2-AuNP, the surface of m-SiO2 is modified by aminosilanes to generate a positive electric field, by which the unconjugated and partially-PEGylated AuNPs with the net negative charges are able to be attracted to the surface of m-SiO2. For the synthesis of AgNP-GO, the cysteamine-functionalized and bovine serum albumin-functionalized AgNPs with positive surface charge are used to combine with negatively-charged GO. Material properties of individual nanoparticles, such as physical size distribution, number concentration, colloidal stability, and surface charge, can be characterized using a combination of electrospray-differential mobility analysis, transmission electron microscopy, x-ray photoelectron spectroscopy, and zeta potential analysis. The uniformity and the corresponding loading of the assembled constructs were characterized using the electron microscopy and inductively-coupled plasma mass spectrometry, respectively. The work provides the fundamental understanding useful in the synthesis of m-SiO2-AuNP and AgNP-GO constructs for the emerging applications (e.g., chemo-radioactive therapeutics, anti-bacteria products).

Electrostatic assembly of functional nanoparticles for biomedical applications

251st National Meeting (2016)

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