Rare-earth upconverting nanoparticles (UCNPs) transform near infrared into UV-visible light via multiphotonic processes, and simultaneously display promising magnetic resonance and nuclear imaging capability. Significant research efforts are underway to design innovative theranostic agents, which integrate the attractive diagnostic features of these nanomaterials with light-activation strategies for drug delivery and photodynamic therapy.1 In this contribution, we will discuss our most recent advances in the development of UCNPs as bone-targeting multimodal imaging probes, and demonstrate their potential for the near infrared photoactivation of antitumor metal-based prodrug candidates.2 References 1. Zhou, J.; Liu, Z.; Li, F. Chem. Soc. Rev. 2012, 41, 1323. 2. Ruggiero, E.; Hernandez-Gil, J.; Mareque-Rivas, J. C.; Salassa, L. Chem. Commun. 2015, 51, 2091. Acknowledgments Spanish Ministry of Economy and Competitiveness (grants CTQ2012-39315 and Ramón y Cajal Fellowship RYC-2011- 07787) and FP7 Marie Curie Actions (MC CIG fellowship UCnanomat4iPACT, grant no. 321791). COST Action CM 1105 and 1403 for fruitful discussions.

Upconverting nanoparticles as platforms for multimodal imaging and metal-based photochemotherapy

251st National Meeting (2016)

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