We have been interested in the arylation of weakly acidic C-H's catalyzed by heterobimetallic catalysts with palladium and main-group metals (Li, Na, K) under basic conditions. These catalysts exhibit increased reactivity in oxidative additions and enable the control of regioselectivity in reductive eliminations. The application of these catalysts to a variety of challenging C-H arylation reactions will be presented. Mechanistic experiments and computational studies will be discussed to shed light on the nature of the increased catalyst reactivity.

Application of heterobimetallic catalysts to C-H functionalizations

251st National Meeting (2016)

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