This investigation will involve the synthesis of several putrescine analogs produced in 95% and 100% ethanol as the solvents. These nucleophilic substitution reactions with alkyl or acyl halides will produce bis(1,1,1-trifluoroethyl), bis(1,1,1-trifluoropropyl), and bis(1,1,1-trifluorobutyl) putrescine. In this study, 95% or 100% ethanol were used as the greener reaction solvents, which allowed for production of the polyamine analogs to proceed in a less toxic environment. There are many advantages for using alcohols over traditional volatile organic solvents in these synthetic reactions. Alcohols are preferred solvents as they are more environmentally friendly, can be reclaimed or recycled, and reactions are run at lower temperatures. It was also found, in this work that the use of 100% ethanol increased the product yield dramatically when compared to the more toxic solvents used in previous studies in our laboratory.<br/>

Synthesis of three bis(trifluoroalkyl) putrescine analogs using 95% and 100% ethanol

251st National Meeting (2016)

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