In the past decade, chromatographic columns based on solid-core particles technology have reemerged as the technology of choice for achieving high efficiency separations owing to the efficiency gains afforded by solid-core particles over comparably sized fully porous particles. However, the efficiency gains are not always evident, depending on analyte, column selection, method, and instrumentation.  This talk outlines efforts to broaden the efficiency gains afforded by solid-core particles beyond the evaluation of neutral analytes under ideal chromatographic conditions. Advanced bonding technologies will be discussed and, in particular, the talk will focus on improvements in performance, selectivity and stability of solid-core particles based columns.

Improvements in solid-core particle technologies

251st National Meeting (2016)

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