Paper microfluidic analytical devices (μPAD) have shown promise for meeting the ASSURED standard (affordable, sensitive, specific, user-friendly, rapid and robust, equipment free and delivered) for diagnostic technology called for by the World Health Organization. Additionally they can be easily transported and rapidly disposed of. Here we report our work developing a urine-based test for d-lactate, a metabolite produced by the parasite that causes Malaria. Our method uses a coupled enzyme assay which can be optimized to detect d-lactate at a variety of physiological concentration ranges. The results can be measured colorimetrically using an inexpensive camera or using a UV-vis reflectance probe. We will present our efforts to optimize this assay and make it robust for a developing world context.

Development of a paper microfluidic analytical device (μPAD) for detection of D-lactate in urine

251st National Meeting (2016)

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