Electron-spinning technique enable to obtain cyclodextrin (CD) fibers with high surface area and porosity. These fibers can be functionalized through host-guest chemistry via interactions of hydrophobic CD cavity with bioactive peptide molecules. In this study, aligned and non-aligned electrospun CD fibers were functionalized with laminin mimetic peptide molecules as being complex bioactive scaffolds for neural tissue engineering. The physical and chemical characterizations of the bioactive peptide functionalized fibrous CD scaffold are completed using different techniques such as FT-IR, ITC binding experiment, XPS and elemental analysis etc. In addition, we aim to understand the effects of both alignment and bioactivity of the designed fibrous structures on cellular behaviors including viability, adhesion and neural differentiation.

Functionalization of electrospun polycyclodextrin fibers with bioactive peptide molecules and their biological applications

251st National Meeting (2016)

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