Immunotherapy has attracted tremendous attention in recent years to treat many challenging diseases including cancer. As a new comer in this area, our group recently has explored how to use nanotechnology to assist immunotherapy. On one other, we have developed antigen loaded nanoparticles, some of which could be tracked by imaging systems with high sensitivity, as potential vaccines to trigger in vivo immunotherapy. For example, using upconversion nanoparticles (UCNPs) as the antigen carrier, we have realized ultra-sensitive in vivo tracking of DCs, which in the meantime could be stimulated by nanoparticles to induce strong immunological responses after be administrated into animals. On the other hand, we have tried to combine photothermal therapy with immunotherapy using nano-agents which not only exhibit strong near-infrared (NIR) absorbance for efficient photothermal conversion, but also serve as nano-adjuvants to promote the immunological responses. Stimulated by the tumor-associated antigens released after photothermal tumor ablation, the triggered immunological responses if in combination with anti-CTLA4 therapy to suppress the activity of regulatory T cells could result in effective inhibition of tumor cells remaining in the body, promising for treatment of cancer metastasis. References: [1] C. Wang, L.G. Xu, C. Liang, J. Xiang, R. Peng, Z. Liu, Adv. Mater. 2014, 26, 8154–8162 [2] L. Cheng, C. Wang, L. Feng, K. Yang, Z. Liu, Chem. Rev. 2014, 114, 10869–10939

Nano-theranostics for photothermally triggered immunotherapy against cancer

251st National Meeting (2016)

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