Porphyrins are large aromatic compounds composed of four conjugated pyrrole rings. Derivatives can be formed by adding different side-chains to the periphery of the porphyrin structure. Porphyrins and their derivatives have shown to be successful in photodynamic therapy. This project entails the addition of a series of hydroxy-amines to the porphyrin core, H<sub>2</sub>TPPC. The characterization of these novel water-soluble porphyrins using UV-vis, infrared (IR), and nuclear magnetic resonance (NMR) spectroscopies has been carried out. Additionally, the purity of the compounds was ensured via high performance liquid chromatography (HPLC). Finally, the cytotoxicity of these novel porphyrins on TC-71 Ewing’s Sarcoma cells under both light and dark conditions was determined using MTT assay.

Synthesis, characterization, and cytotoxicity of a series of novel water-soluble porphyrins

251st National Meeting (2016)

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