Plants have been used as a source of traditional medicines for thousands of years. Due to these traditional uses, the chemical compositions of essential oils of Psidium guajava ans six Syzygium sp. were examined and evaluated for in vitro H1N1 and dengue inhibition activities. The essential oils from the leaves were extracted using hydrodistillation method and amalyzed by head-space gas chromatography-mass spectrometry. The extracted essential oils were then subjected to in vitro H1N1 neuraminidase inhibition activity by using MUNANA assay, The dengue activity was evaluated by using DEN-2 NS2B-NS3 protease assay. Monoterpenes were found in all the leaves studied ranging from 7.63% in S. grandes to 77.24% in S. samarangense. The sesquiterpenes were found the lowest in S.cumini (6.23%) and the highest in S. malaccense cultivated jambu susu (69.94%). The H1N1 neuraminidase inhibition activity was observed in three plants namely S. jambos, S. malaccense cultivated jambu susu and jambu bol with 0.8%, 14.4% anf 16.8%, respectively at 250 ug/mL samples. Essential oils of five Syzygium sp. inhibited the protease activity at 250 ug/mL with the highest inhibition of 54.1% by S. cumini. In conclusions, the essential oils from Syzygium sp. could be useful as a potential source of dengue protease inhibitors.

Chemical compositions of essential oils of Psidium guajava and Syzygium sp. and their in vitro antivirus activities

251st National Meeting (2016)

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