The modeling of metalloenzymes has taken a prominent place in organometallic and coordination chemistry. As a result, the development of new ligand systems bearing biologically-relevant donor functionalities has become a growing area of research. We have sought to synthesize a variety of ligand systems bearing N, O, and/or S-containing moieties. In particular, the synthesis of imine-containing compounds has provided a series of novel ligands which were allowed to react with Ni2+, Fe3+ and Pd2+ ions. Ligands and ligand precursors have been characterized by 1H and 13C NMR, and IR spectroscopy, and x-ray crystallography. The preferences of these species for metal complexation will be presented.

Synthesis of new imine-containing ligand scaffolds for metalloenzyme mimics

251st National Meeting (2016)

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